Sentence examples for mutation is considerable from inspiring English sources

However, summed over all genes, the input of variation by mutation is considerable".

The variation is considerable.

10– 12 Interestingly, even in the subtypes of ALS caused by SOD1 mutations, there is considerable phenotypic heterogeneity.

Among BRCA1 and BRCA2 mutation carriers, there is considerable variability in both the age at diagnosis and the incidence of breast and ovarian cancers, even among women who carry the same BRCA1 and BRCA2 mutation [ 6- 8].

Despite the fact that people with this mutation exhibit no clinical abnormalities [28], testing for this mutation is of considerable clinical importance.

Apparently, the molecular response to a single gene mutation is of considerable complexity, and certainly much more complex than detectable using current experimental approaches.

It is now well documented that there is considerable variation in mutation rates (e.g. Hodgkinson and Eyre-Walker 2011), but we suspect that the implications of this for developmental bias are rarely appreciated.

It was recently shown that there is considerable variation in mutation rates within and between families, which in part can be attributed to the age of the father at the time of conception.

It is now clear that by the time a tumour is clinically apparent, it has accumulated a large number of mutations, many of these are not within gene coding sequences (the significance of which is yet to be understood) and there is considerable variation in mutations between tumours even those in the same tissue.

The implications of a new, pseudoderivative-based adaptive mutation rate are considerable.

Here, it is indicated that the prevalence of HNF4α mutation among Iranian patients with clinical MODY is considerable.