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These similarities suggest that the mechanism of mutation is conserved across species.
The effect of the B allele at this lead-SNP was in the same direction (increasing or decreasing) for the associated traits across different breeds, indicating that linkage phase between this lead-SNP and the causal mutation is conserved across breeds (Additional files 1, 2, 3, 4, 7, 8, 10 and 12) suggesting that the SNP is very close to the causal mutation.
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Several AT1R residues reported to differentially affect signaling pathways upon mutation are conserved polar residues in the transmembrane domain suggested to be involved in the conformational changes associated with receptor activation [12], [16], [17], [18], [19], [20].
The aim of this study was to determine if the canine GL-1 cell line and samples obtained from dogs diagnosed with ALL contain FLT3 mutations, to compare any identified mutations to those previously reported in both canine and human leukemia patients, and to determine whether the functional consequences of FLT3 mutation are conserved between dogs and humans.
It is also possible that the distribution of beneficial amino-acid mutations is conserved across species, but that biases in estimating α result in a substantial underestimation of the rate of adaptive amino-acid divergence in D. melanogaster.
The 1918 H2H mutations were conserved in later human strains, which gradually accumulated additional adaptive changes throughout the 1930s and 1940s.
These mutations are conserved and preferentially expressed in RNA and are likely the driver for tumor biology and may potentially be used for outcome prediction and treatment targets.
These mutations were conserved when this sequence was compared with other public sequence databases of diverse G. soja lines from Korea [ 8] and China [ 35].
Our results suggest that a RIP-like process and the specific nucleotide context for mutations are conserved within the Pucciniomycotina subphylum.
These mutations were conserved when this sequence was compared with other public sequence databases of diverse G. soja lines from Korea [ 8 ] and China [ 35 ]. Figure 7 Expression pattern of root specific candidate genes on chromosome 6.
Whereas these tumor-specific mutations were conserved in the patient's lymph node- and liver metastases, the heterozygous sequence variants were lost in metastases derived cell lines (H-STS and L-STS), indicating a lack of selective pressure to maintain the mutations (probability of < 0.1% for the random loss of 10/10 mutations) during in vitro-cultivation.
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