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The lifetime risk of ovarian cancer in patients with a BRCA1 mutation is between 40 and 60%% [ 1, 3] compared with the general population risk of 1.8 % [ 4].
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Hopwood et al. (1985) showed that mutation frequency is higher when the survival rates from UV mutation are between 10 and 0.1%%.Since the aim of this work was to increase the innate capability of the strain to secrete/produce more cellulases, 2-DG, an antimetabolite, was used to screen for catabolite repression-resistant mutants (Montenecourt and Eveleigh 1975).
22 The estimated rate of APC new mutations is between 4 and 9×10 mutations/gametes/generation, 23 and equal susceptibility for mutagenesis during spermatogenesis and oogenesis has been described.
Previously, it was felt that the risk for desmoids tumors was most severe in patients with FAP whose mutations were between codons 1444 and 1578 [ 12].
The frequency of KRAS mutations was between 0 and 9% in several phase II trials of cetuximab in combination with chemotherapeutic agents in advanced gastric or OGJ adenocarcinoma [ 9- 11, 25].
Using simple sequence length polymorphism (SSLP) markers, we found that the pgr7 mutation is located between NGA162 and GAPAB on chromosome 3 (Figure 6A).
This mutation is located between the nuclear export signal and catalytic domain of MEK1 [ 77].
The mutation is located between zinc finger 1 and the C-terminal RING finger domain at position 1605 of the published sequence (Fakharzadeh et al, 1991).
The mutation is localized between the HMG-box and the glycine proline-rich seglycine proline-richnal of the protein (Fig. 1B).
Similarly, out of the 78 mutations found between B and A1, four are non-synonymous and only one non-synonymous mutation is shared between O and A1 (Additional file 7, Table S7, and Additional file 8, Table S8).
With deep sequencing data, the variance of VAF for each mutation is smaller and relationships between the mutations become apparent.
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