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The allele frequency of the FCN3 + 1637delC mutation is approximately 0.01 in the Danish population [19].
The risk of developing this cancer in carriers of an MLH1 or MSH2 mutation is approximately 5%.
It appears simpler at present to assume the simplest model, namely that the level of mutation is approximately (statistically) constant.
The fixation probability of a new positive mutation is approximately 2 s (Haldane 1927, based on Fisher 1922), with the mean time to fixation being strongly related to the inverse strength of selection, s−1.
Given that the probability of manifesting a mutation is approximately proportional to the number of carriers in the founders, we can treat it as introduced by only one founder.
Similar(55)
In skeletal muscle, the frequency of the MERRF mutation was approximately 80% (Fig. 3b), which is consistent with the threshold mutational load sufficient to cause a biochemical defect in oxidative phosphorylation13.
The I/σ ratio of reflections versus the resolution for the Arg301Glu mutation was approximately 30% greater over the entire resolution range than that obtained for any of the other mutations or for the wild-type.
When the tissue samples were segregated as to country of origin, the frequency of this mutation was approximately 2-fold higher in hyperplasia and carcinoma samples from Japan than from the United States, where the incidence, clinicopathological characteristics, and risk factors for endometrial carcinoma differ dramatically.
The average negative effect of mutation was approximately 15% of the control lifespan.
The average positive effect of mutation was approximately 10% of the control lifespan.
Consistently, it was reported that the rate of human mtDNA mutation was approximately 17 times greater than that of nuclear DNA [ 24]. mtDNA mutations have been detected in different types of tumors including lung adenocarcinoma.
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