Sentence examples for mutation is appropriate from inspiring English sources

Because of the large increase in glutamate sensitivity and a demonstrated lack of coupling between the T6′S mutation and the ligand binding site, we concluded that incorporation of T6′S as a background mutation is appropriate for measuring large loss-of-function mutations in the GluClβ receptor.

Furthermore, genetic testing for such mutations is appropriate only in cases meeting certain criteria.

Patients with EIF2AK3 and KATP channel mutations were appropriate for gestational age (birth weight between −2 s.d. and +2 s.d)., whereas patients with mutations in GCK, PTF1A, INS and 6q24 methylation abnormality were small for gestational age (birth weight <−2 s.d).

Since our subjects all had genotype C virus, this high frequent BCP mutation rate is appropriate.

In summary, mutation screening is appropriate when sonography during pregnancy reveals findings suggestive of a skeletal dysplasia, especially when the karyotype does not explain the abnormal sonographic findings.

Specific mutation analysis is appropriate to confirm the clinical diagnosis of achondroplasia for appropriate diagnosis, prognosis, and genetic counseling, especially when the karyotype does not explain the abnormal prenatal sonographic findings.

Although the methodology used for the mutation screening is appropriate and was shown to be sensitive and robust [23], a recent report exposed some limitations to the current methods, which included false negative calling due to human error in data and sample handling [12].

For example, it was proposed that a 2-fold higher substitution rate of 1.3 × 10− mutations per site per year is appropriate to date the insertions of LTR retrotransposons (Ma and Bennetzen 2004), and the nucleotide substitution rate for the tb1 intergenic region of maize was estimated at 2.9 3.3 × 10− (Clark et al. 2005).

However, it is unclear whether it is appropriate to use mutation rates based on contemporary data to date this transition because comparative rates of substitution in bacteria have been shown to be lower than those based on mutation accumulation experiments (Ochman 2003).

The resulting library of beta-galactosidase (β-gal) mutants consisted mostly (∼80%) of hypomorphs, suggesting that the mutation rate was appropriate for directed evolution applications.

Consideration of prophylactic surgery is appropriate for both BRCA1 and BRCA2 mutation carriers.