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IF STANDARDISATION IS one way to make financial innovations catch on, mutation is another.
In addition to large chromosomal alterations, genomic mutation is another important genetic alteration which contributes to tumor initiation and progression.
Mutation is another operator that is responsible for modifying genes within a chromosome at low rates and creates random variations in some chromosomes.
The origin of new genetic variations by mutation is another case in point: it is possible to predict probabilistically that new variation will arise, but it is not possible to predict whether a mutation will occur at a particular nucleotide site.
PTEN loss-of-function mutation is another critical factor causing RTK inhibitor resistance.
MEF2B mutation is another target, but we did not analyse this because of the sample limitation.
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Crossover and mutation are another two important basic operators used in any GA.
In addition, the host genotype variability in the gene encoding PrPC (PRNP), as determined by polymorphisms and mutations, is another recognized causal factor for phenotypic heterogeneity [ 2, 12].
The additional presence of isolated, nonnucleoside RT inhibitor (NNRTI /nucleoside RT inhibitor (NRTI) resistance mutations is another indication for the transmission of drug-resistant viruses, although they and the K65R mutation were not found in the same viral genomes.
Steric effects like HER2 mutations that lack the extracellular domain or have internal domain mutations are another mechanism.
TP53 mutations are another potential mechanism of resistance to anti-EGFR under evaluation (Oden-Gangloff et al, 2009).
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