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This mutation is analogous to the previously reported Glu914Lys kinase domain mutation in ERBB2 found in a glioblastoma [11].
Interestingly, this novel mutation is analogous to the γ2 subunit mutation that causes inherited cardiac arrhythmias and cardiac hypertrophy [21], [24], [25].
The FGFR4 mutation is analogous to a reported tumor-specific somatic mutation in ERBB2 and is located in the same exon as a previously reported kinase domain mutation in FGFR4 (Pro712Thr) in a lung adenocarcinoma cell line.
The Fas DD V254N mutation is analogous to the mutant allele of Fas in lpr-cg mice.
The Ser197Tyr mutation is analogous to the Ser203Tyr mutation that was previously introduced into GFP to generate the red-shifted YFP (11).
The former mutation is analogous to the mutation T315I in ABL and the mutation T790M in EGFR, where the original amino acid moiety was replaced with a bulky one to interfere with the binding of an inhibitor.
Similar(54)
We investigated the impact of a single β-catenin mutation, which is analogous to the situation found in human patients.
In case 3, the cooperative lineage expansion case with late mutator mutation, the situation is analogous to case 2 except that the mutator mutation occurs after the onset of lineage expansion, during the period when additional oncogenic mutations are occurring towards reaching a fully malignant phenotype.
This mutation is thus analogous to the well-characterized rod Pde6β rd1 mutation.
A bovine E211K mutation is important because it is analogous to the most common pathogenic mutation in humans (E200K) which causes hereditary Creutzfeldt – Jakob disease, an autosomal dominant form of prion disease.
The V254N mutation of the Fas DD is analogous to the mutant allele of Fas in lpr-cg mice.
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