Sentence examples for mutation is additionally from inspiring English sources
The C77W mutation is additionally linked to Klippel-Feil syndrome (KFS), a skeletal developmental disorder in DBA patients (Cmejla et al., 2011).
We also investigated how signaling via the Erk pathway was affected by the F595 mutations and detected that pErk1/2 levels were elevated in nonstimulated sorted cells expressing JAK2 V617F, but decreased once F595A mutation was additionally introduced.
Strains with the Δ tonB:: FRT-Km-FRT mutation were additionally supplemented with 88 μM iron (provided as FeCl3·6H2O) and 0.005 mM cobalamin.
The proportion of private mutations is additionally increased by purifying selection, which differentially affect mutations of different functional annotations.
In the case of cancer research, the interpretation of mutations is additionally complicated by the dynamic nature of tumor progression, and also the need to distinguish between mutations associated with the initiation of the cancer and others that accumulate as the tumors evolve.
By dHPLC scanning, 12 novel mutations were additionally identified.
All strains were PCR verified, and mutations were additionally verified by DNA sequencing.
The identified lethal mutations were additionally used to test the sensitivity of Pindel.
In the present study, PIK3CA mutations were additionally assessed in exons 1 and 2. PIK3CA mutations were identified in 151 (33.0%) of the 458 samples, in line with previous studies in which PIK3CA mutations were found in 10 to 40% of breast cancer cases [ 3, 4, 8].
Pain and temperature symptoms in the combined FTLD cohort and in the subgroup not associated with C9orf72 mutations were additionally associated with atrophy of right anterior temporal cortex; while temperature symptoms (but not pain symptoms) in the FTLD cohort were associated with atrophy of right mid-insula (Supplementary Fig. 2).
These cysts are notable for biallelic VHL inactivation in renal tubular epithelial cells; whereas, clear cell renal cancer is additionally characterized by mutations in genes involved in the PTEN-mTOR pathway [ 13, 14].
