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Previous studies from our group have shown ND complex mutations, particularly, the ND2 mutation, is accompanied by increased ROS generation and hypoxia inducible factor-a (HIF-1α) stabilization and anchorage independent growth [33].
In AtFH21, the K1601 mutation is accompanied by a large insertion in the flexible linker.
In addition, BRAF mutation is accompanied by an elevated kinase activity, which increases ERK phosphorylation [ 32, 33].
Furthermore, we show that a single escape mutation is accompanied by a significant impairment of viral fitness, which may be rescued by mutation at a second covariant site.
This mutation is accompanied by greatly impaired GTP binding, thereby changing the intracellular conformation of TG2 (Liu et al. 2002; Ruan et al. 2008; Gundemir and Johnson 2009).
If this mutation is accompanied by a modestly more bulky and polar residue at position 324 (valine to glutamine or asparagine), then an even more significant decrease in activity is observed.
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Selection of the Y143R/C mutation was accompanied in all three patients by the T97A mutation.
Mutant larvae were analysed by in situ hybridisation, in order to verify if the omr mutation was accompanied by abnormalities in sensory vesicle structure and by impairment of ocellus photoreceptors.
Four independent reversions of this mutation were accompanied by reversions in lifespan phenotype.
In these patients, the rtA181T mutation was accompanied by the sW172* mutation in the S reading frame.
This mutation was accompanied by an amino acid change from aspartate in Se_At4 and Se_At5 to valine in Se_At1-3.
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