Sentence examples for mutation introducing a from inspiring English sources

The Hha structure was also destabilized by a mutation introducing a negative charge at the position of C18.

This point-mutant was generated by PCR using oligonucleotides carrying the Arg to Ala mutation in position 491 as well as a silent mutation introducing a BglII site to facilitate subcloning.

The authors demonstrated that this mutation, introducing a premature stop-codon, destabilizes mRNA inducing its decay and reduces mRNA expression.

They both carried a pathogenic mutation introducing a premature STOP codon in the exon 11 of the BRCA1 gene.

Focusing on gene-disrupting mutations, we found a mutation introducing a premature stop codon in the RPMS1 gene of the NA19315 sequence (nucleotide C160T, residue Q54X).

Hence, the selection of an adaptive mutation introducing a functional splice site, and consequently the emergence of a novel intron which results in an in-frame deletion between the novel donor and previously described acceptor splice site constitutes the first-time alternative splicing has been associated with an adaptive gain-of-function in IAV.

When we follow one of the proposed mutations in [ 29], in which p27 is mutated and it is always off, the mutation introduces a situation where both CycD and Rb might be inactive.

This mutation introduces a downstream STOP codon leading to a severely truncated protein lacking the DNA binding domain (Supplementary Figs 9.4 and 9.5).

The wnt2O mutation introduces a stop codon at residue Q40 likely producing a null mutant.

The fsn-1 hp1) fsn-1 hp1introduces a stop codon before the SPRY domutationsultintroducesrotein null allele.

The Arg975Trp mutation introduces a large hydrophobic patch in H1' α-helix, whereas loss of Leu-954 provokes a distinct conformation of the extended coil.