Sentence examples for mutation into one from inspiring English sources

It follows that ZFNs can simultaneously introduce addition, deletion and mutation into one and same targeted allele.

Given that the second BRCA2 allele is consistently deleted from cancer cells [37, 38], we used gene targeting to introduce the corresponding P3240L mutation into one allele of GgBrca2, while deleting the second allele, to recapitulate cancer-associated genetic alterations.

Group 2 and 3 students only incorporated mutation into one of the two tests (the final or the midterm, respectively), and both groups did so with a lower propositional accuracy than their group 1 peers.

The rationale of the yeast-based model for CFTR-ΔF508 was thus to recapitulate its defective folding and trafficking by introducing an equivalent mutation into one of its yeast homologs, thereby allowing isolation of modifier genes thanks to the tremendous power of yeast genetics.

Through our additive combination of rare mutations into one event, we have found 15 mutational events causal on pathway level at the cut of FDR q value < 0.1.

We were not able to summarize the viral resistance mutations into one main result by lack of standardization.

An untargetable shRNA was designed by inserting five point mutations into one of the most effective shRNAs to control for possible nonspecific effects of the RNAi approach.

Affinity maturation of the Cry1A toxin can be enhanced by introducing several different loop-derived high-affinity-generating mutations into one molecule.

We anticipate the generation of mutants with more than 100 greater binding affinities for BtR than the wild-type toxin by integrating multiple mutations into one molecule.

Because many genetic mutations in DLBCL occur at a very low frequency, it would be more efficient to group several mutations into one mechanistic category, such as activation of well-defined oncogenic signaling pathways [ 65].

Site-directed mutagenesis was used to introduce point mutations into one (C286A or C286S) or both (C286A,295A (AA) and C286S,295A (SA)) cysteine residues that control CD44 palmitoylation and incorporation into rafts.