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These results suggest that disrupted neurotransmission in the SCN due to the Bdr Snap-25 mutation influences important hypothalamic outputs, potentially causing desynchrony between the brain and the periphery (106).
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This study demonstrated that random mutagenesis and bioselection procedures could be used to identify mutations that influence important properties of bacterial Rubisco; these residues would not have been identified by other methods.
Nowadays, the experimental way of random mutagenesis and bioselection could be used to identify mutations that influence important properties of Rubisco [ 13, 28- 30], but the vast amount of candidates and the repetitive lab work make the process slow, unpredictable and tedious.
From the standpoint of therapy, it will also be important to determine whether the mutation influences response or the development of resistance to tamoxifen or other anti-estrogen therapies.
Therefore, these results indicate that the smg11 mutation influences grain size and weight in rice.
How this additional mutation influences data interpretation remains incompletely understood.
It is equally important and unsurprising that mutations influencing cell cycle checkpoints, angiogenesis, apoptosis, and telomere synthesis are common across many neoplasms.
45 Combining both aspects allows defining specific and important regions within the protein where mutations influence each other.
If such mutations influence the cost of subsequent resistance mutations, as they did in our experiment, then a better understanding of epistasis between resistance elements and other types of mutations will be important for predicting the likelihood that multi-drug resistant bacteria will persist following different types of treatment.
How these mutations influence WNK4 function is unknown.
It will be important to understand whether the likely targets of transformation are initially unipotent or multipotent and whether the mutation repertoire influences their differentiation potential and self-renewal capacity.
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