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The docking results suggest that L418A mutation influenced the binding interactions of the substrate with several residues in the active site of MtbICL.
Neither mutation influenced the integrity or quantity of daf-16b or daf-16f transcripts.
Because of the low density of mutations expected in mutants isolated from mutagenesis screens, we assumed only one causal mutation influenced the phenotype of interest in each mutant.
Because SV clustering and maintenance of the RP are believed to occur partly through oligomerization of SynI with other Syns (1), we asked whether the Q555X mutation influenced the ability of SynI to oligomerize with other Syn isoforms.
To verify whether the c. 1033 + 2184 C > T mutation influenced the aberrant splicing of CD46, we introduced alternative alleles into the pSPL3 exon trapping vector and found that the pSPL3 construct vector with the C-allele permitted the retention of the 48 bp intron 8 sequence while the T-allele construct did not permit this retention.
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The aim is to uncover a strain that would be drug-resistant due to a mutation influencing the alternate target, while still being affected in mycolic acid cyclopropanation like the parent strain.
It is therefore possible that the mutation influences the overall risk of metastasis.
The A467T mutation influences the interaction of POLG1 with POLG2 and the W748S mutation reduces both processivity and DNA binding.
These data suggest that independent of the cellular system and species background (mouse, rat, or human), the G12V mutation influences the regulation of the same cellular processes.
To evaluate if the 52+2 Cys mutation influences the binding of the hapten into its binding pockets, affinity measurements were performed.
The aim of the first part of the study was to examine whether the presence of a BRCA mutation influences the rate of spontaneous abortions.
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