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IS-insertion into genes relevant to natto production might be more plausible than spontaneous mutation induced in these genes, since mutation hot regions have not yet been identified in Marburg 168 genomes [ 3].
The presence of the mutation in both sectors indicates that the mutation induced in G1 by the radiation was represented in both strands of the duplex prior to replication.
With the aim to investigate the molecular crosstalk occurring between precancerous and normal cells in vivo, we took advantage of the clonal analysis methods that are available in Drosophila for studying the phenotypes due to lethal giant larvae (lgl) neoplastic mutation induced in different backgrounds and tissues.
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It involved an assortment of biological experiments, including one concerned with mutations induced in the offspring of insects exposed to ionizing radiation in space.
Although null mutations induced in the mouse do not confer a severe skeletal phenotype, they do result in mild brachygnathism in the double mutant; thbs1−/−, thbs2−/− [34].
Somatic mtDNA mutations induced in the PolgAmut mouse cause premature aging phenotypes without altering reactive oxygen species production, suggesting that respiratory chain dysfunction itself is the etiologic factor in many age-related diseases [22].
For example, mutations induced in the gene encoding Δ12 fatty acid desaturase (FAD2).
We also determined the number of mutations induced in the genomes by these treatments.
Crops with improved traits are being developed by screening for mutations induced in candidate genes [ 1- 5].
Here we demonstrate this approach to find the causative mutations induced in four novel ENU lines identified from a recent ENU screen.
However, no mutations were found in domain II of 23S rRNA in this study and it is not known whether the mutations induced in vitro arise in clinical samples [ 20].
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