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Compared to controls, the db/db mutation induced a dramatic increase in cytolipid vacuole volume and density within all ovarian follicular layers.
Compared to HRx controls, the db/db mutation induced a dramatic increase in cytolipid vacuole volume and density within all ovarian follicular granulosa cells (GC) and uterine endometrial epithelial (UEE) layers.
Mutant TDP-43 (A315T mutation) induced a motor axonopathy characterized by short axonal outgrowth and aberrant branching, similar, but more severe, than that induced by mutant SOD1.
In all but two cases, the combination of the modifier insertion mutation induced a statistically significant change in the C24 GluRIIA phenotype (Figure 7 and Figure S5 and S6).
In the case of JAK2 K539L/F595A, the presence of the F595A mutation induced a decrease in the initial proliferation rate, but by day 7, these cells had regained the same proliferation ability as JAK2 K539L (Figure 4B).
The maternal mutation induced a frameshift (c.1040delG) and produced an enzyme with reduced activity.
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This R299Q mutation induced an orientation change of the 2 zinc fingers and abolished its physiological function as a transcription factor.
These results suggest that the dominant mutation induces a deep change of the ratio between lamina and marginal growth.
The BRAF V600E mutation induces a conformational change in the kinase domain which in turn results in constitutive activation of the pathway without RAS activation.
Surprisingly, we found that the mutation induces a change in the conformation of a nearby surface loop resulting in stronger lattice interactions, consistent with the improved crystal quality.
Background: The diabetes (db/db) mutation induces a hyperglycemic hyperinsulinemic endometabolic environment that promotes hypercytolipidemic, utero-ovarian involution in C57BL/KsJ mice, resulting in reproductive sterility and eventual organoatrophy.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com