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The dramatic reduction in the expression of the glucosinolate biosynthesis genes by the myb28myb29 double mutation indicates that MYB28 and MYB29 contribute equally to activation of these genes.
In general, detection of a somatic mutation indicates that a new allele provides a differentiation, growth or survival advantage for the cell population(s) in which it appears.
However, the high loss of cells in our simulations of male and female embryos with a homo/hemizygous Tsix-stop mutation indicates that these mice will most likely not be viable.
Pdzk1 knockout mice have liver-specific reduction of SCARB1 protein as does this mutant; however, in vitro analysis of the mutation indicates that the regulation of SCARB1 protein in this mutant is independent of PDZK1.
Therefore, a change in Keq consequent to a mutation indicates that the perturbation caused the AChR to change this free energy difference, and, hence, the relative structure or dynamics (entropy) in the vicinity of the mutation, in the A2C↔A2O reaction.
The constitutive photomorphogenic phenotype of cop1 mutation indicates that COP1 acts as a negative regulator of photomorphogenesis [ 13, 18].
Similar(43)
Following a hunch, they decided to ask whether Mr. Byrne had had the mutation, too, and whether the mutation indicated that the four families were related to him.
Electrophysiological analyses of KCNQ1 P320H and the previously reported KCNQ1 P320A mutation indicate that both channels are non-functional and suppress wild type IKs in a dominant-negative fashion.
Mutational analysis of the EcR LBD) revealed that ligand entry and exit is affected differently by the same point mutation, indicating that different pathways are used for association and dissociation of the ligand.
Of the white flowered lines, 78 carried the intron 6 splice site mutation, indicating that it is common (Fig. S3B).
Expression of this construct rescued a bah-1 mutation, indicating that the modification did not disrupt function.
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