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The observation that frequency of mutation increased with histologic grade suggests these patients may have experienced a longer or more intense exposure to oxidative damage induced by reflux.
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In neurons from the neurologically normal people, the number of genetic mutations increased with age in both brain areas.
The prevalence of the HBc141 149 mutations increased with the disease progression in HBV-infected patients (Fig. 5D).
The percentage of patients with p16 mutations increased with increasing histologic grade.
The presence of TP53 mutations predicted progression to AML and the proportion of cells carrying mutations increased with disease progression [ 40].
It is noteworthy that the fraction of beneficial mutations increased with robustness, at least in the simple environment, whereas the magnitude of beneficial mutations did not significantly change.
We confirmed that the number of mutations increased with repeat length at a much higher frequency than was expected from the occurrence of such repeats in the genome.
These mutations were predominantly paternal in origin, and the number of mutations increased with increasing paternal age, consistent with the known increased risk of ASD to children of older fathers.
In contrast, in their longitudinal analysis, the prevalence of obesity increased from 37% at 20 years to 60% at >40 years, indicating that the penetrance of these mutations increased with age (25).
The results showed that the frequency of null mutations increased with the concentration of Mn2+ and the cycle number of error-prone PPCP within the ranges tested (Table 1).
On the other, if germ-line mutations increase with age, older males could produce relatively unfit offspring.
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CEO of Professional Science Editing for Scientists @ prosciediting.com