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Interestingly, the p.R76Q mutation increased significantly dimerization (127.8±6.6%), whereas the p.R76W mutation dramatically decreased it (30.5±9.0%).
APP carrying the E682K mutation increased significantly the Aβ1 42/Aβ1 40 ratio in cell-based assays.
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The prevalence of D310 mutations increased significantly with the number of cytosines in the matched normal tissue sequence (P=0.02).
The prevalence of tumour D310 mutations increased significantly with the number of cytosines in the matched normal tissue sequence.
Moreover, in the present study, the prevalence of tumour D310 mutations increased significantly with the number of cytosines in the D310 sequence of matched normal tissues.
Interestingly, mutation frequencies increased significantly (P<0.05) on exposure to H2O2 in the presence of higher CO2 levels (Fig 2).
The number of student models incorporating mutation, however, increased significantly on the final compared with the midterm (from 39 to 65%; chi-square test of independence, p < 0.0001).
Combined expression of pCas9 and pTpds in 1 1 ratio provided mutations that increased significantly when Cas9 and cgRNA were coexpressed using the construct pCtpds1 (Table 1).
Since we had already shown that a D2447N mutation increased binding significantly (144%), we made a triple mutant (D2385K/D2386N/D2447N) but this bound no better than the D2447N mutant alone.
The number of identified pseudogenes and mutations in the sequenced strain also increased significantly.
The trfA DNA, PCR-amplified from EPI300, encodes the full-length (382 amino acid) TrfA protein and contains the G254D "copy-up" mutation demonstrated to increase significantly copy-number induction [ 9, 14].
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