Sentence examples for mutation including the from inspiring English sources

We show that ANC1 defines a new branch in the PRR pathway, one that is error-free, promotes cell survival in the presence of DNA damaging agents, and suppresses both induced and spontaneous mutation, including the expansion of CAG triplet repeats.

The clinical implications of the secondary RAS mutation, including the potential efficacy of anti-EGFR antibody therapy, remain unknown.

In contrast, we see that in p63, the helix is indeed propagated due to the F25L mutation including the formation of full length helical structures.

Three (30%) tumours were found to harbour the KIT exon 10 mutation, including the patient with CR (13 months +) and two patients with SD.

Global reduction in H3K27me3 was observed in all 12 H3F3A K27mutantntumorsrs while H3K27me3 was not globally reduced in tumors without the mutation including the H3F3A G34R mutant tumor (Figs.  1, 2; Supplementary Figure S1 and Tables S1 and S2).

In light of these data and our current findings, we suggest that 17-AAG, or other Hsp90 inhibitor, should be considered as a viable therapeutic alternative in all instances of EGFR and ErbB2 kinase domain mutation, including the 3 4% of NSCLC that express exon 20 insertions in either of these proteins.

One of early examples of an activating mutation includes the protein Ras which has been found to be constitutively active due to a mutation in the corresponding gene.

The latter mutation includes the glutamic acid 961 (in segment M9), which is thought to be important for the Na+-specific site III.

However, these mutations, including the CDK and PAK sites mutated individually or in combination, did not confer cell lethality or temperature-sensitivity, as all strains grew like the wild type control at all temperatures tested (Figure 2C).

Two of these mutations, including the well-studied R89L, are known to severely compromise binding affinity for ras.

He gives a potted history of the contemporary hipster while noting its mutations, including the "hipster primitive", a fusion of pastoral innocence with the dominant ironic mode of hipsterism.