Sentence examples for mutation in transgenic from inspiring English sources

In colon cancer cell lines, cyclin D1 antisense reduced cellular growth (Arber et al, 1997) and cyclin D1-deficiency conveyed resistance to tumour formation induced by APC mutation in transgenic mice (Hulit et al, 2004).

Future studies could investigate the role of Munc18-1 depresynapticsynaplasticityicity for information processing in neuronal networks, by making use of the PKC-insensitive mutation in transgenic mouse approaches.

It is able to partially complement the Arabidopsis npr1-2 mutatinn in transgenic Arabidopsis plants in a leaf infection assay and translocate into nucleus upon SA induction in the same manner as the endogenous Arabidopsis NPR1 protein.

Driven by the constitutive CaMV35S promoter, the cacao TcNPR1 gene partially complemented the npr1 mutation in transgenic Arabidopsis plants, resulting in 100 fold less bacterial growth in a leaf infection assay.

Expression of human APP with single or double mutations in transgenic mouse lines leads to the formation of diffuse and neuritic plaques, which resemble the amyloid pathology seen in brain material from AD patients [2].

Functional evaluation of three analogous human TEX11 missense mutations in transgenic mouse models identified one mutation (V748A) as a potential infertility allele and found two mutations non-causative.

Study of these mutations in transgenic animals suggested a therapeutic potential for drugs that interfere with Wnt signaling to increase bone mass.

A Me-PaMuFind-It web tool has been developed to estimate the number and possible effect of passenger mutations in transgenic mice of interest (Vanden Berghe et al. 2015).

The expression of the human amyloid precursor protein (APP) with single or double mutations in transgenic mouse lines leads to the formation of neuritic plaques with clusters of dystrophic neurites and glial recruitment that resembles the amyloid pathology seen in AD brains [ 4, 28].

Many mutations identified as causing hypertrophic cardiomyopathy have been investigated with recombinant proteins incorporating the mutation or in transgenic mouse models.

4 In addition to the ability of gene mutation assays in transgenic animals to detect organ-specific genotoxicity, these assays are also able to detect mutations after only a short duration of repeated exposure because clonal expansion of mutant cells is not necessary.