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The third and fourth isolates, with resistance to macrolides, clindamycin, quinupristin-dalfopristin, and the highest telithromycin MICs of all the isolates, had an A2058G (Escherichia coli numbering) mutation in the sequence of the gene corresponding to the domain V of the 23S rRNA as well as the 6 amino acid insert in the ribosomal protein L22.
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Because mitochondrial DNA is passed down from mother to daughter without combining with male DNA, any changes in the sequence of nucleotides are due to mutations.
Missense mutations in the coding sequence of Piezo1 lead to diseases, such as xerocytosis and lymphatic dysplasia3,17,41,42,43,44,45.
Mutations in the MRE sequences of three of these CES that disrupt function in vivo abrogate interactions with the LBC.
In these patients, the sequence of CD40 ligand demonstrated mutations.
During that time, mutations occurred randomly in the DNA sequence of organisms in both lineages.
Many genetic diseases are caused by mutations, or changes in the DNA sequence of a gene, that make it produce a dysfunctional protein product.
Defined mutations in the 5′ nontranslated sequence of Sindbis virus RNA.
We saw similar patterns of mutations in the 1a sequences.
To demonstrate these results, mutations were introduced in the G-rich sequence of the template to abolish G4 formation.
They also sequenced mutations in tumors from 100 of the patients studied, and found that in 82 patients, the same mutations found in the blood corresponded with those found in the tumor tissue.
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