Sentence examples for mutation in the core of the from inspiring English sources

Exact(1)

Electrophoretic gel mobility shift experiments showed that the Arabidopsis AtPum2 PUM-HD binds with high affinity to BoxB of the Drosophila Nanos Response Element I (NRE1) RNA, whereas a point mutation in the core of the NRE1 resulted in a significant reduction in binding affinity.

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Several explanations for the surprising absence of missense mutations in the core of the TID exist.

P53 mutations tend to be clustered in the core of the protein, where it binds to DNA, and they have similar effects on its shape.

Researchers writing today in Nature Medicine used a two-step method: They introduced a combination of mutations to stabilize the core of the hemagglutinin stem.

Previous work has shown that mutations in the core of an fnIII domain from human tenascin (TNfn3) reduce the unfolding force of that domain significantly: The composition of the core is apparently crucial to the mechanical stability of these proteins.

Mutations in the core and the periphery of the protein affect similar aspects of folding for both variants, suggesting a common trajectory with folding of the core region followed by the folding of the periphery.

While λ-repressor is known to tolerate any hydrophobic mutation in the core, we find MarA drastically less tolerant to core mutation.

A selective growth advantage imparted by an acquired mutation is at the core of cancer development.

Mutations in the hydrophobic core of the evolved α-factor prepro-leader enhanced functional expression, whereas some mutations in the mature protein improved its catalytic capacities by altering the interactions with the surrounding residues.

Importantly, many residues within the hydrophobic core are associated with drug resistance, and mutations in the core likely affect the dynamic properties of HIV PR and potentially affect the ability of PR to bind inhibitors and substrates.

Other mutations in the core region are synonymous and most of them (7/10) are positioned in the region encompassing aa 99 124).

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