Sentence examples for mutation in the context of the from inspiring English sources

In contrast, the effect of introducing the GLE mutation in the context of the uATG−6 differed when measured in HeLa or in HeLa/CIITA cells.

When tested in the ex vivo retinal explant assay, the CRX mutation in the context of the fusion construct did not lead to loss of promoter activity (Figure 8A-B).

The functionality of the proximal Pit-1 response element was tested by mutation in the context of the pGL3B-MMP-1-1633/-1 construct (see Additional file 1).

The specific deletion was not detected among these samples, indicating that it is not a recurrent mutation in the context of the Greek population.

(C ) The MGS-like mutation in the context of the Orc6 C-terminal domain (CTD) alone significantly reduces the affinity of the Orc6-CTD for ORC1 5.

Introduction of mutations into YACs by homologous recombination coupled with the ability to produce transgenics provided a system to analyze the effect of the mutation in the context of the whole locus within an animal model.

The cybrid cell model allows studying the effect of mtDNA mutations in the context of the same nuclear background [34].

The effect of point mutations in the context of the insertion of additional residues can be analyzed accordingly.

Surprisingly, in HeLa/CIITA cells, mutation of the GLE element in the context of the DPE-L1/2 mutation does not affect promoter activity (Figure 3C, lower panel).

Here we report on our analysis of this mutation in the context of SI.

The presence of 40%% BRAF and KRAS mutations in the context of 71 90 % estimated tumor cellularity in case P4 and the presence of 31 % BRAF mutation and 30%% KRAS mutation in the context of 51 70 % estimated tumor cellularity in case P5 suggest that the kinase-impaired BRAF mutation and the activating KRAS mutation were present in the all the tumor cells.