Sentence examples for mutation in specimens from inspiring English sources

Epithelial cells containing the TP53 mutation in specimens PO3 and PO67 also displayed loss of heterozygosity (LOH) of the wild-type BRCA1 or BRCA2 alleles, respectively (Figure 1D; Supplemental Table S1).

Antiviral resistance mutations in specimens from patients with H7N9 infection have been reported recently.

Not only can it provide a result very quickly utilising a technique readily available in most pathology laboratories, but it also allows accurate determination of BRAF mutation status in specimens containing a very low number of tumour cells and has the advantage of quantification and cellular localisation of the mutated BRAFV600E protein within a lesion.

A real-time one step RT-PCR assay using single nucleotide polymorphism (SNP) probes was developed to detect this mutation in respiratory specimens.

In summary, we have presented a methods comparison study of three assays for the detection of KRAS mutation in FFPET specimens of CRC.

For example, many centers additionally conduct testing for the BRAF V600E mutation in CRC specimens that demonstrate loss of the MLH1 and PMS2 protein staining by IHC, as presence of this mutation is strongly and negatively associated with LS.

To further determine the relevance of the mutation in clinical specimens, we sequenced all ten exons of RIC8A in 127 tumour samples obtained from patients with early-stage breast cancer.

Considering the importance of the PI3K/AKT pathway in mediating survival and antiapoptotic signals in the B-cell types of chronic lymphocytic leukaemia (CLL) and acute lymphoblastic leukaemia (ALL), we sequenced the AKT1 exon 3 for the above mentioned mutation in 87 specimens, representing 45 CLLs, 38 ALLs and 4 prolymphocytic leukaemia (PLL) cases, which are all of B-cell origin.

The method used by the outside laboratory to identify KRAS mutations was regular sequencing, which explains why the KRAS mutation in that specimen was not originally detected.

Optimization of OLA probes to accommodate polymorphisms in regional HIV variants improved OLA performance, and comparison to the USA results showed successful implementation of the OLA in Zimbabwe for detection of NVP resistance mutations in DBS specimens.

Similarly Menegon et al. [39] found seven mutations in 71 specimens.