Sentence examples for mutation in multiple from inspiring English sources
This is the first report of the detection of an identical IDH2 mutation in multiple tissues and TP53 mutation in anaplastic astrocytoma in a patient with Maffucci syndrome.
This technology allows for the limitation of the duration of Cas9 expression in a biallellic mutation in multiple target loci [ 69].
Genotyping of this mutation in multiple generations of B6 offspring demonstrated that inheritance of the Rasgrp1 Anaef allele was well correlated with the immunological abnormalities described above and below.
However, uncontrolled deamination activity by A3B on genomic DNA can have a detrimental effect, as A3B has been reported to be an enzymatic source of mutation in multiple cancers including breast, lung and cervical cancers [ 24– 34].
Recent studies have recognized a role for TNFRSF1A mutations in Multiple Sclerosis (MS).
As the title of Jaenisch's paper declared triumphantly, "One-step generatiof of mice carrying mutations in multiple genes".
Additionally, the related KMT NSD1 was recently discovered to harbor point mutations in multiple cancers, including HNSCC and AML (Dolnik et al., 2012; Yan et al., 2011).
Mice carrying mutations in multiple genes are traditionally generated by sequential recombination in embryonic stem cells and/or time-consuming intercrossing of mice with a single mutation.
Kandoth and colleagues characterized the presence of significant mutations in EMT-related genes and discovered mutations in multiple TGFβ-related pathways (Smad4: 2%; TGFBR2: 3%; ACVR1B: 1.3%; SMAD2: 1%; ACVR2A: 0.7% of the 301 HNC tumors sampled) [90].
Delhommeau and colleages then sequenced TET2 in patient tumor samples, becoming the first group to identify TET2 mutations in multiple myeloid neoplasms, including MDS (19%), MPNs (12%14%%), and sAML (24%).
Wang et al. simultaneously interrupted five distinct alleles in mouse embryonic stem cells, with an efficiency of 80%% to achieve the one-step generation of animals carrying mutations in multiple genes [1].
