Sentence examples for mutation in motif from inspiring English sources

Mice harboring a mutation in motif A of the polymerase domain were embryonic lethal in homozygotes and experienced genomic instability in heterozygotes as compared to wild types.

In addition, the single point mutant K230E, bearing a substitution in motif I (Walker A); and the double mutant DADA (D346A/D349A), bearing a double mutation in motif II (Walker B) were also constructed.

However, the capacity of eIF3 to stimulate termination-reinitiation, particularly from a defective TURBS, was confirmed, including a TURBS rendered defective through a point mutation in motif 1. Together, these data support the view that efficient termination-reinitiation requires both mRNA-rRNA interactions and the participation of eIF3.

Results implicated that mutation in motif 1a was strengthening its confirmation while motif V was loosely bound.

To investigate role of mutation in motif imperfection, SNPs localized within microsatellite loci were identified from the dbSNP database (see Materials and methods).

In yeast, a point mutation in motif IV of the conserved residue Cys in NOP2 leads to accumulation of mutant nop2 protein-RNA complexes and cell death [ 54, 67].

Mutations in motif A of the polymerase domain also expressed a mutator phenotype and hypersensitivity to hydroxyurea and methylmethane sulfonate in budding yeast [12], [13].

Thus mutations in motif 4, coordinating both template and incoming dNTPs, seem ideally poised to modify RT fidelity.

The 2 mutations in motif VII of the CaHEV RdRp domain are L(1432 M and I(1434 V.

We identified mutations in motif I (2A9-14T145I, the Walker A box), a common motif found in proteins that bind and hydrolyze NTPs.

However, motif Z does not contribute to CTCF recruitment, since targeted mutations in motif Z do not influence the level of CTCF binding.