Sentence examples for mutation in model from inspiring English sources

Experimental induction of secondary mutation in model organisms such as bacteria and yeast has proven to be one of the most rewarding approaches to study gene function and regulation.

Experimental approaches for deciphering the function of human genes rely heavily on our ability to generate mutations in model organisms such as the mouse.

Our central objective was to compare miRNA expression in colon tumors that arise due to chronic inflammation and germ line mutations in model systems.

The involvement of homologous proteins in vertebrate lens development was subsequently elucidated by the characterization of mutations that cause congenital human or murine ocular disorders and their comparison to mutations in model organisms [1].

Transposons are widely used for generating mutations in model organisms.

Mutations in model and other plant species are important resources for functional genomics studies.

Several studies have characterized the fitness effects of mutations in model cellular organisms [ 14– 16] and viruses [ 17– 20].

Data from experiments on the induction of specific-locus mutations in model systems are used in genetic risk assessment to estimate potential adverse effects in the human population.

In recent years, several sequence-guided DNA endonucleases have been applied to generating targeted mutations in model organisms including Drosophila [ 13].

Based on our study, we propose the following method to rapidly clone causative mutations in model systems with large genomes, such as Xenopus, zebrafish, and mice.

Several general strategies have been used to obtain reduction-of-function or knockout mutations in model organisms, including insertional mutagenesis [ 3] and RNA suppression [ 4], which have been widely used in plants.