Sentence examples for mutation in many from inspiring English sources

Therefore, despite using the same secretory compartments as other cells, the dependence of neurons on the secretory pathway for synaptic transmission, outgrowth and remodelling of dendrites and axons, combined the vast distances involved, means the impact of mutation in many secretory pathway genes has a greater impact on neuronal, rather than non-neuronal, cell function [142].

KRAS2 (KRAS) is a signal transduction GTPase, turned permanently on by somatic mutation in many cancers, including breast [ 45, 46].

In addition, activation of ERK1/2 can be caused by KRAS mutation in many cancer types [ 28].

Deep sequencing of exons 5 8 of the TP53 gene showed a strong correlation between the p53 IHC staining score and TP53 gene mutation in many tumours.

The SCGB1A1P gene had most inter-individual variability and contained a non-sense mutation in many animals, suggesting that SCGB1A1P has evolved into a pseudogene.

BRCA1 5382insC, an Ashkenazi Jewish founder mutation and the most frequent mutation in many European populations, was identified in only one Belgian family.

In contrast, "signature E," denoting C>G mutations at Tp CpA, Tp CpC and Tp CpT trinucleotides, is a late onset mutational signature, contributing a large fraction of subclonal mutations in many patients.

Scientists had assumed that the dramatic alterations in beak shape, height, width and strength would require the accumulation of many chance mutations in many different genes.

Almost certainly, each had accumulated mutations in many other genes, at other moments, over the course of their lives.

Many individuals with lupus have a genetic predisposition to it, and in fact the disorder is associated with a number of mutations in many different genes.

They are comparing the mutations in many examples of each type, to find which are common to a type (and thus, presumably, causative) and which are mere accidents.