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The latter property was proposed to be potentially relevant to the D7N Tottori Japan mutation, in light of the greater susceptibility of asparagine to spontaneous conversion into isoAsp [38].
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The K2A mutation was designed in light of the strong tendency of the N-terminus region to interact with sequestered PIP2 lipids, as observed in the MD simulations of STX in PM membranes.
Issue that must be addressed prior to publication: The virological and cellular phenotypes of the R44/I45 mutation should be tested in light of the newly observed μ1 interaction.
The finding that the response was inhibited by the A809V mutation is somewhat surprising in light of the results from the molecular pharmacology studies and further illustrates the complexity of the relationships between putative allosteric sites on mGlu5.
Therefore, oral contraceptive use in women with BRCA1 mutations should be considered in light of any planned prophylactic surgery.
According to [ 1], "mutations in two genes produce a phenotype that is surprising in light of each mutation's individual effects.
These studies indicate the importance of non-coding mutations in ASD, particularly relevant in light of recent genome-wide studies (see below).
The interpretation of these mutations as exposing a cilia/centrosome targeting motif needs to be modified in light of the R650C mutation reported in this paper.
In light of the mutation in PIK3CA, a trial with a combination targeting the PI3K pathway could also be considered.
In light of carnivore mutation rates, these synonymous distances suggest that the most recent common mitochondrial ancestor for Northern California, Southern California, and the majority of Rocky Mountain haplotypes date to approximately 16.7 kya (9.0 - 31.3 kya).
In light of the mutation-selection balance that sets initial r allele frequency as described previously, r alleles with effects sufficiently large to confer survival on Bt crops could be rarer in highly susceptible pests than in less susceptible pests.
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