Sentence examples for mutation in leptin from inspiring English sources

These results demonstrate that the V145E mutation in leptin results in less adiposity, but more severe insulin resistance, than the truncated premature stop at codon 105 of leptin.

To compare the metabolic outcome of the V145E mutation in leptin with that of the nonsense mutation at codon 105 of leptin identified in Leptinob/ob (ob 1J)) mice [6], we examined their metabolic parameters in accompany with their respective wild-type littermate controls.

We explored the distribution of Q223R mutation in leptin receptor gene of amoebic liver abscess (ALA) patients of North India.

8 The ob/ob mouse is homozygous for a recessive inactivating mutation in leptin, a satiety hormone, and this mutation causes hyperphagia, obesity, and hyperglycemia.

In the paper entitled " A novel mutation in leptin gene is associated with severe obesity in Chinese individuals," Y. Zhao et al. detect a novel mutation H118L in leptin gene in Chinese subjects.

DDAH-1 expression was reduced during diabetogenesis in the liver, kidney and adipose tissue of mice with a point mutation in leptin receptor, an experimental motel of type 2 diabetes [ 53].

Several animal models of monogenic obesity involve mutations in leptin (Leptinob/ob mice) or its receptors (Leprdb/db mice and fa/fa rats).

Humans with mutations in leptin or leptin receptor show hypogonadism (Farooqi and O'Rahilly, 2009).

These control subjects had been tested for mutations in leptin, leptin receptor, and MC4R.

74 Loss-of-function mutations in leptin receptor cause similar clinical phenotypes to those of leptin deficient patients.

Mutations in leptin disrupt this homeostatic feedback loop and result in massive obesity, both in rodents and humans.