Sentence examples for mutation in key from inspiring English sources
While tumors such as lung cancer and chronic myelogenous leukemia develop resistance by a mutation in key signaling pathways in the majority of the malignant cells [7], [8] there is no current available data regarding whether RCC resistance is accompanied by similar tumor cell mutations.
Hence, the multiple changes observed in the ewst1 transcriptome could be due to point mutation in key regulator gene(s) with pleiotropic effects.
Moreover, previous experiments using temperature-sensitive mutations created artificially in Caenorhabditis elegans demonstrated how GSD could rapidly evolve into ESD as a consequence of a mutation in key sex determining genes [ 9].
Two patients had activating mutations in key signaling pathways (STAT5B (p.N642H) and CAMK2G (p.T306M)).
This effect can be alleviated by mutations in key amino acids of the U-binding pocket.
The color-coded list identifies documented mutations in key viral genes, along with literature citations and a description of how the mutation is believed to change biological function.
Mutations in key conserved TOG2 determinants abrogate the ability of CLASP mutants to rescue bipolar spindle formation in Drosophila cells depleted of endogenous CLASP.
Like species, changes in languages can be tracked through the fate of certain words, just as mutations in key genes can tell a species' history.
Although the development of genetic diversity in cancer stem cells has not been well defined, SCS is now being used to study cancer stem cells to identify mutations in key functional pathways promoting tumorigenesis [31].
Cancer, as well as other human disorders, has long been considered to result from the consequence of genetic mutations in key regulatory genes that reside in pathways controlling proliferation, cellular differentiation, DNA damage and repair.
The scientists screened the family for mutations in key genes involved in the circadian clock, and identified two rare variants of the PERIOD3 (PER3) gene in members suffering from SAD and advanced sleep phase.
