Sentence examples for mutation in isolation from inspiring English sources

No individuals carried the G376A mutation in isolation.

Whatever the impact of the W62L mutation in isolation, it seems possible that it could modulate translational efficiency to the lower level of activity seen in eIF4ER, when in combination with the other mutations.

Similar to tti2 -F328S, the F3590I mutation in isolation had no apparent phenotype.

It is possible that having 2 mutations exerts a stronger effect on DNA methylation than does either mutation in isolation or that the relation between MTHFR 677C>T genotype and DNA methylation differs in subjects with and without cancer.

Here we have found that 6% of PTEN mutation/variant-positive CS/CSL patients were also found to have germline SDHx variants, and the presence of SDHx variants appear to further modify PTEN mutation cancer risks over those of PTEN mutation in isolation.

This view is supported by the observation that Apoer2−/− mutations in isolation already result in a noticeable cortical and hippocampal phenotype, unlike Vldlr−/− mutations [9], [25].

The regulatory mutations in isolation all increase transport, in line with a common reduction in negative regulation by RpoS.

While the A63V+R193H double activator combination slowed relaxation beyond that of either mutation studied in isolation, the net effect was not precisely additive on a one to one basis as the sum total of relaxation times for single R193H and A63V myocytes (355+246 = 601 ms, 75% Relaxation) was ∼17% greater than those measured in A63V+R193H dual gene transfer myocytes (493 ms).

In contrast, fitness effects of the rplS mutation introduced in isolation into the ancestor of the 40k strain does not track overall fitness patterns for this strain, again consistent with the presence of multiple fitness-relevant mutations in this strain.

This was recently shown to result in lymphoid hyperplasia in a mouse model harboring a tyrosine 641 mutation, but in isolation from other oncogenic events, this was insufficient to drive overt lymphoma.

Mutations that in isolation have a neutral or even negative effect on long-term clonogenicity (passengers) might be 'selected' if they co-occur with a fitness-conferring mutation or are advantageous in the context of other mutations (epistatic effect).