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We identify individual recombination and mutation events, and assess the relative contributions of recombination and mutation in generating single nucleotide polymorphisms (SNPs).
First, using the model we can quantify the role of mutation in generating skew so that the effect on composition, for example codon bias, can be assessed.
First, it quantifies the role of mutation in generating skew so that its effect on composition, for example codon bias, can be assessed.
The relative contribution of recombination to mutation in generating protein diversity was measured as a ratio of recombination to mutation per protein and per HVR.
Other measurements of the extent of LGT within a species suggests that recombination plays a much greater role than mutation in generating diversity in MLST loci for B. pseudomallei.
The relative contributions of selection and mutation to the observation of parallel evolution remain unresolved, but our data help shed some light on the role of mutation in generating standing variation.
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The clonal theory of cancer development and the general role of DNA mutations in generating cancer cell clones had been established by 1986 when I was working as a junior pathologist.
Evolutionary biologists have long concentrated on the role of new mutations in generating new traits.
The board game ACAGATATA is entirely focused on the effects of random mutations in generating genetic and phenotypic diversity.
One outstanding question is the relative preponderance of coding versus regulatory mutations in generating phenotypic change.
At this point, it should be noted that A1 and B2 in figure 4 represented lethal mutations but they may also represent the loss of the duplicate genes A0 and B0, respectively, because they have the same effect as that of lethal mutations in generating reproductive isolation.
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