Our study failed to analyze the mutation in distinct-morphology neoplasm with different location because of limited sample size, which is the limitation of our study.
Similarly, numerous genetic diseases harbouring mutations in distinct components involved in ribosome biogenesis, collectively referred as "ribosomopathies", are prone to developing cancer [ 9].
Finally, the authors demonstrate that independently evolved yeast clones have mutations in distinct sets of genes, which do not appear related in any obvious way.
Mutations in distinct regions of the RCL of the Z variant of α1-antitrypsin at P14P12 and P4–are able to significantly affect accumulation of polymers in cells.
We were also able to identify the effect of mutations in distinct sectors with variations in the clinical signs of a disease.
The different CLN subtypes are caused by mutations in distinct CLN genes encoding proteins important for lysosomal function and cellular homeostasis [ 4].
Based on these findings, we predicted that missense alleles encoding Top2 proteins with mutations in distinct functional domains might display interallelic complementation.
It is difficult to compare the frequency of mtDNA mutations in different studies analysing mtDNA mutations in distinct cancer types, because most of these studies only analysed parts of the mitochondrial genome, mostly the D-loop.
Nevertheless, we consistently observed a similar phenotype of impaired DDR in 4 different ccRCC cell lines (RCC-ER; -FG2; -AB; -MF) carrying inactivating mutations in distinct regions of SETD2 (Duns et al., 2010).
Since mutations in distinct components of the piRNA pathway appear to differentially impact the reporter construct, we also analysed the expression levels of the sensor in stem cells of vas, aub and rhi mutants.
It is possible that hearing loss in these patients is due to rare deleterious homozygous mutations in novel hearing-associated genes, or to codominant, compound heterozygous, or non-allelic non-complementation of heterozygous mutations in distinct genes previously not known to affect hearing.
