Among women who had received radiotherapy for their first breast cancer (n = 169), we identified 24.3% mutation carriers, in contrast with only 12.8% among those who had not received radiotherapy (n = 78).
The paucity of fixed mutations is in contrast with the results from another allopolyploid species, C. bursa-pastoris, in which a large proportion of high-impact mutations (such as stop codon gained) were fixed8.
Recent studies demonstrated greater sensitivity to platinum based chemotherapy for patients with p53 mutation, in contrast to previously believed [ 74].
It is well established that BRAF mutation, in contrast to KRAS mutation, is associated with MSI [ 9, 10, 16, 33] and female sex [ 10, 33, 34], and our findings further validate this.
We found an association between IDH and TP53 mutations, but we showed TP53 mutation correlated with astrocytic phenotype, in contrast with IDH mutation more associated with the oligodendroglial phenotype.
The P-ERK1/2 levels were comparable to those seen in human melanoma cell lines with oncogenic BRAF or NRAS mutations, in contrast to a cell line with wild-type BRAF and NRAS.
Two common polymorphisms in regulatory sequences of the connexin40 (gene) gene have been reported to predispose to familial atrial standstill if they occur in conjunction with a SCN5A mutation, in contrast, carrying only a single genotype was relatively benign (Groenewegen et al, 2003).
The reduction of mutagenesis by a ruvA mutation was at all sites, in contrast with the case for umuC where only specific sites were affected.
Thus, in contrast with mutations which affect the function of all isoforms, mutations in exons 8 10 may display a lower penetrance and later age of onset leading to more clinical overlap with common forms of Type 2 diabetes mellitus (T2D).
Aberrant DNA methylation is induced at specific promoter CpG islands (CGIs) in contrast with mutations.
In contrast, with CASQ2R33Q mutation, compromised interactions between RyR2 and calsequestrin markedly lower the threshold of luminal Ca2+ concentrations for the termination of SR Ca2+ release.
