Sentence examples for mutation have resulted from inspiring English sources

More specifically, DNA shuffling and other methods of genetic recombination and mutation have resulted in the improvement of proteins of therapeutic interest.

This suggests that the W243F mutation has resulted in a greater reduction in the efficacy of HEMADO for all responses measured compared with NECA.

The nas4x-1 mutation had resulted in an approximation of the - Fe wild type situation in roots and of the + Fe wild type cell physiological situation in leaves.

The recent evolution of ECSA strains with the E1 A226V mutation has resulted in several outbreaks of chikungunya in widely distributed geographic regions.

These data indicate that the mutation has resulted in a structural reorganization of the protein and that it has formed a more flexible layer upon binding to the SLB (DOPC/DOPE/POPC/DOPS).

In order to assess whether mutation had resulted in a gross change in channel function, the potency of ATP for each histidine mutation was assessed (Fig. 5C) and none of the single or double mutations produced a concentration response curve that differed significantly from wild type.

Using Cake and an intersection of any two or more callers, we made 1225 calls (per sample 613 ± 42), of which 254 were from a reference call set representing a subset of positions (264) covered by the capture baits where a somatic mutation had resulted in a non-synonymous change; a sensitivity of 96.2% (Table 1, Supplementary Fig. S4).

Previous studies on ALS patients lacking SOD1 mutations have resulted in detection of occasional Lewy body-like structures staining for SOD1 [27], [28], [29], [29] as we also found, or failure to detect any inclusion staining [23], [25].

The R-TS/A mutant showed elevated ligand-independent signaling than WT RIG-I, but retained response to ligand, suggesting that the mutations have resulted in relaxed repression of CARD domain.

A further five mutations have resulted in putative alloacceptor changes.

In any case, it is unlikely that binding site mutations have resulted in consistent hemizygous PCR amplification at so many loci and across numerous studies.