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Exact(10)
Five of these mutations, including one nonsense, one deletion, two splice-site, and one missense mutation, have not been previously reported.
The LOH status of the patients in this study has been presented previously [24], [25], [27], [28], but the associations between LOH and p16 mutation have not been presented previously.
13, 14 However, cancer cells that acquired the gatekeeper mutation have not yet been found.
To date the methods used to identify the BRAF mutation have not taken this potential genetic heterogeneity into account.
One key design challenge is the fact that most individuals at risk of carrying an ADAD mutation have not chosen to have genetic testing.
Cells with this AKT1 mutation have not been observed to have mutations at PIK3CA; a similar scenario is also frequently observed with RAS and BRAF mutations [ 144].
Similar(50)
If a beneficial mutation has not spread throughout an entire population, one possible interpretation is that the mutation arose relatively recently in the population's history.
Although Drosophila has been helpful in understanding several human neurodegenerative disorders, a loss-of-function mutation has not been identified that leads to insoluble CNS protein aggregates.
The frequency of GJB2 mutations and of the del(GJB6-D13S1830) mutation has not been established among the Ecuadorian mestizo population diagnosed with autosomal recessive non-syndromic hearing loss.
Until now, the internal structure of the K haplogroup, especially the major subclade defined by the M9 mutation, has not been well characterized.
The gene corresponding to the mutation has not yet been identified.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com