Sentence examples for mutation have induced from inspiring English sources

Its overexpression and mutation have induced bortezomib resistance in several in vitro models.

Compared with std-gRNA, tF7 1 gRNA has induced a decreased mutations in cultured cells, but has significantly increased the efficiency of generating mutant mice.

We verified that at least one mutation had been induced in three embryos by direct sequencing.

The DNA damage caused by albicidin may rapidly have induced the mutation of DNA gyrase A gene and thus stopped the process of genome erosion, possibly explaining the distinctive genomic characteristics of X. albilineans.

First, a higher therapeutic use of intravenous antibiotics in the control population could indeed have created a higher selective pressure for pre-existent resistant bacteria or may have induced more mutations leading to resistance.

Another lower-chlorinated congener (PCB-3) has been shown to increase the mutation frequency in the liver of male Big Blue rats, an observation supported by in vitro studies in which metabolites of this congener have induced genetic mutations, chromosome breaks, chromosome loss, and polyploidization (Robertson and Ludewig 2011).

Spermatozoa originating from exposed spermatogonia did not contain DNA adducts; however de novo mutations had been induced (p = 0.029), specifically GC-TA transversions, characteristic of B[a]P mutagenesis.

V198M mutation has been described as inducing CAPS with a heterogeneous phenotype which variably responds to increasing doses of anti IL-1 medication [ 21- 23].

Simple genetic analysis of these traits is further complicated by the persistence of the BTG-active phenotype after the inducing mutation has been segregated away.

Given that DAP12 is mainly expressed before P3 and that glutamatergic synapses are generated post-natally [24], we hypothesized that microglial dysfunction induced by DAP12 mutation has impacted the prenatal development of neurons with delayed consequences on synaptic function.

Indeed, the yeast rad21 mutation has been correlated with the disruption of DNA-damage-induced-checkpoints.