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Into these mutants we introduced GSK3 mutations, and in neither case armXM19, GSK3 (Fig. 2 C-C"'), nor armF1a, GSK3 (Fig. 2 E-E"') did the additional mutation have an effect on epithelial patterning.
Surprisingly, iPSC-derived cardiomyocytes from an asymptomatic carrier of a HERG mutation have an abnormal phenotype.
Female breast cancer patients with a BRCA1/2 mutation have an increased risk of contralateral breast cancer.
Carriers of the CHEK2 c.1100delC mutation have an increased risk of bilateral breast cancer and male breast cancer [ 75].
For example, women who are carriers of the BRCA1 mutation have an approximately 85% lifetime risk of developing breast cancer.
Carriers of a FAP mutation have an 80 100% chance of developing colorectal cancer during their lifetime (Haggitt and Reid, 1986).
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Superhero movies, with their emphasis on mad-science mutation, have a retrofuturist appeal.
Men who inherit this mutation have a significant increase in risk of prostate cancer.
Patients with metastatic melanoma, 50% of whose tumours harbour a BRAF mutation, have a poor prognosis.
Men who carry a BRCA gene mutation have a 7-10% lifetime risk of breast cancer, which is approaching the general population women's risk of breast cancer.
Women with a mutation have a 65% risk of developing breast cancer before age 70 [9].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com