Sentence examples for mutation has limited from inspiring English sources
The lack of a relationship between PIK3CA mutation status and 2-week/pre-Ki67% in all the data sets suggests that the presence of a PIK3CA mutation has limited, if any, impact on the likelihood of benefit from presurgical anastrozole treatment in patients with primary BC.
We show that the effective evolutionary parameters can provide good estimates of U and of the mean effect of beneficial mutations only when the distribution of effects of arising mutations has limited variance.
Consequently, mutation screening strategies aiming to detect only known mutations have limited value.
This is because mtDNA mutations have limited capacity to pass through the germ-line.
Along with this finding, one may argue that many of the fixed mutations have limited potential function which simply reflects the time of divergence between the studied populations.
Our observations indicate that PIK3CA hotspot mutations have limited potential to predict intrinsic tamoxifen resistance in the adjuvant treatment of ERα-positive, postmenopausal breast cancer patients.
As both are large multi-exon genes, with inactivating mutations occurring across the entire coding region, the consequent cost of BRCA1/2 mutation screening has limited mutation testing to those who are most likely to have a mutation based on their family history of cancer.
Both data illustrate that p53 mutation detection has limited clinical utility for the detection of bladder tumours, but that voided urine specimens provide a good material for studying p53 in a prognostic attempt.
It has been shown that vemurafenib that targets BRAF V600E) mutation is effective in treating melanoma but has limited success in treating colon cancer despite the same BRAF V600E) mutation.
This has limited the possibility to investigate co-occurrence of mutations.
The fact that GRN mutations produced in mice do not display all the features of the human disorder has limited progress towards effective treatments for FTD.
