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The effect that a mutation has depends on the cell in which the mutation occurs.
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It has depended, and continues to depend.
It has depended on two in particular.
Rather, epistasis is defined as a mutation having different effects depending on the identity of residues at other sites.
MYD88 L265P mutation has been commonly reported in recent studies of WM, with frequencies of 70 100%, depending on the method and tissues used for genetic analyses.
The clinical penetrance of the underlying mutations has been shown to depend upon the level of wild-type PRPF31 mRNA expression displayed by the patient (Vithana et al. 2003; Rivolta et al. 2006; Liu et al. 2008).
Although genes that can cause either hypertrophic or dilated cardiomyopathy (depending on the mutation) have been identified, most cases of dilated cardiomyopathy remain idiopathic in terms of their genetic origin.
The L642Q mutation had varied effects on the abundance of γ-tubulin at the centrosome, depending on the expression level of the protein.
A mutation had stopped it from functioning.
One mutation had never been reported before.
However, under thermal stress (42.2°C) and low glucose (DM25) conditions in the absence of rifampicin, the mutations had differential fitness effects depending on genetic background.
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CEO of Professional Science Editing for Scientists @ prosciediting.com