Sentence examples for mutation has both from inspiring English sources

However, for ZNV, the E119G mutation has both direct and indirect influences on the drug binding.

Antagonistic pleiotropy, where a single mutation has both beneficial and detrimental effects, can cause diverse outcomes in the evolution of antibiotic resistance in experimental and clinical populations of bacteria.

As has been demonstrated previously in the case of MAPT and GRN-associated FTLD (Rademakers et al., 2007; Beck et al., 2008; Le Ber et al., 2008; Rohrer and Warren, 2011) detailed phenotypic characterization of disease-causing mutations has both clinical and neurobiological implications.

Ventricular tachycardia and VF (VT/VF) complicating AMI as well as arrhythmias associated with Brugada syndrome, a genetic disorder linked to SCN5A mutations, have both been linked to phase 2 reentry.

FoldX analysis of the protein crystal structures indicates that the Pro-to-Ala mutations have both local and long-range effects on the structural stability of residues involved in the architecture of the protein and the active site and in the proton pumping function.

The majority of AML patients with CEBPA mutations have both types of mutations, usually on different alleles.

People with FOXP2 mutations have both impaired expressive and receptive language (MacDermot et al. 2005; Watkins et al. 2002a), whereas expressive language appears to be more affected in patients with FOXP1 disruptions (Hamdan et al. 2010; Horn et al. 2010).

This interpretation is supported by a further analysis of cases reported by Haffty and colleagues [ 28], in which all eight patients with deleterious BRCA1/ BRCA2 mutations had new primary ipsilateral breast cancer, whereas patients without deleterious mutations had both true recurrences and new primary breast cancers (P = 0.06).

TERC and TERT mutations have both been shown to adversely impact telomerase enzymatic function through in vitro assays such as the telomerase repeat amplification protocol [69] and in vitro studies reconstituting telomerase activity with a mix of wild type and mutant TERC suggest that heterozygous mutations can cause disease though haplo-insufficiency [70].

For persons where a known genetic mutation has been identified, both earlier onset of CRC and much higher risk are apparent.

Whereas no mutation has been shown to cause both class 1 and class 2 disease, several mutations have been shown to cause two or more of the sub-classes of class 1 disease (Fig. 1c).