Sentence examples for mutation has become from inspiring English sources

The EGFRT790M secondary mutation has become a leading cause of clinically-acquired resistance to gefitinib and erlotinib.

Since the demonstration that the V617F mutation in the exon 14 of the JAK2 gene is present in about 90% of patients with Polycythemia Vera (PV), the detection of this mutation has become a key tool for the diagnosis of these patients.

With the recent results of randomized trial, IDH1 mutation has become, with 1p19q codeletion, a predictive marker of the response to chemotherapy [ 27– 29].

Genetic counseling and testing for BRCA1 and BRCA2 gene mutation has become an integral part of high-risk patient evaluation and management for hereditary breast ovarian cancer [ 11, 33].

The detection of the JAK2V617F mutation has become an essential tool in BCR-ABL1-negative myeloproliferative neoplasms (MPNs) diagnosis, as it is present in 95% of polycythemia vera (PV) patients and 60% of essential thrombocytemia (ET) or myelofibrosis patients.

Patients with EGFR mutations in exons 19 and 21 have been shown to have significantly higher response rates and improved PFS when treated with frontline gefitinib, and EGFR mutation has become an established criterion for selecting an EGFR TKI as first-line therapy in stage IV NSCLC patients.

In that year the allelic frequency of the disease in the cow population increased sharply because some sires that had been carriers of the mutation had become very popular 2 4 years before.

In 2002, several researchers tried to address this nomenclature problem and the challenges to make more inclusive definitions.A special article by Condit et al. found that mutation had become increasingly negative in connotation since its use in the biological sciences, but particularly over the course of the 20th century [ 22].

Therapy targeting specific somatic mutations has become an increasingly important part of cancer therapy over the past 20 years.

The analysis of KRAS mutations has become a prerequisite for anti-epidermal growth factor receptor therapy in patients with metastatic colorectal cancers.

With the development of tools for genomic analysis, the task of positional cloning ENU-induced mutations has become quite feasible, and this approach has recently been widely applied and highly productive.