This mutation has also been observed in patients receiving ZDV+ddC and ZDV+ddI.
The PLD2 point mutation has also been found in breast cancer [11].
Interestingly, the EPHA3K207N mutation has also been detected in a PDAC sample.
This mutation has also been shown to be associated with reduced expression of CCR5 [15].
Although such mutations are predominantly somatic, a family with a germline T790M mutation has also been described [11].
Compensatory mutation has also been shown to facilitate substantial fitness recovery in mutation accumulation lines and natural populations previously overwhelmed by accumulated deleterious mutations [41] [43].
This mutation has also frequently been observed in viruses isolated in northern Greece where this change has been found in 93% of the viruses analyzed [5].
The S518F mutation has also been identified in a patient from Germany, while the R344C change was found in families from France, UK, Germany and Singapore.
This mutation has also been identified in an Australian NHS family (18).
This mutation has also been confirmed in other ethnic groups [ 7- 9].
This mutation has also been linked to a worse prognosis [ 16].
