Sentence examples for mutation had such from inspiring English sources

If one mutation had such an effect on sleep duration and subsequent cognitive function, couldn't there be more that did the same?

The G268V model predicts that this H-bond is lost and is therefore not surprising that this mutation has such a detrimental impact on the bacterial enzyme).

However, further investigation is required to explain why this specific missense mutation has such a severe phenotype compared with adult-onset SCA5 cases.

For all treatment groups, few mice carried InsG mutations in the liver (3 out of 7), whereas almost all (13 of 16) had such mutations in spermatozoa.

One looked only for BRCA1 mutations in women known to be at particularly high risk (because of their families' or their own medical histories), and found that fewer than 10% of them had such mutations.

No fifth month isolates had such dual mutations.

SDHA and SDHB subunits encode the two physically-interacting catalytical subunits, so it is surprising that their mutations would have such different phenotypic consequences [ 21].

Thus, both I424S and A427D are clear examples of PDB mutations that have such dramatic effects on the stability and structural integrity of the folded UBA domain structure that they are no longer able to directly interact with ubiquitin with any significant binding affinity.

How could a single mutation have conferred such a dramatically new function?

All primary tumours were assessed for ras mutations but only one tumour was found to have such a mutation, which is consistent with previously published data indicating that breast carcinomas contain a low frequency of ras mutations [ 3].

Although this problem can be partially circumvented by removing genes that have such mutations, species-specific microarrays are the only known way to obtain a fair comparison among several divergent species without the loss of any genes.