Sentence examples for mutation had selected from inspiring English sources
In striking contrast, virtually all pediatric ACTs found to be associated with a germline R337H mutation had selected against the wild-type allele [ 4, 5], including that of the grandson of patient 3 (data not shown).
When testing the ten yeast strains with single gene mutations that we had selected (Table 1), we found that PEA hydrolysis was reduced by 49% in yju3Δ, a strain that lacks a serine hydrolase orthologous to the mammalian MGL (Figure 5A).
Analyzing gene expression and the role of individual mutations demonstrated that we had selected for more than multicellularity.
We showed genetically that the mutations identified in four strains were necessary and sufficient for the phenotypes we had selected.
This could have selected mutations faster in subtype B than in C.
Studies with the NS2A mutant demonstrated that it was unable to produce a larger form of NS1 (Nsuggestingesthat thet the mutation had been selected to eliminate a ribosomal frame-shift "slippage site" in NS2A.
We have selected for mutations in two members of the hnwd gene family that suppress self-incompatibility.
Additionally, assessing whether a mutation has been selected against in past human history requires that selection be estimated in realistic demographic scenarios: human demography varies considerably between populations which can affect both the strength of selection and genetic drift.
From the decomposed energy and alanine scanning result, the point mutation has been selected and investigated.
As BRCA1 mutations have been selected against in past populations, negative selection may explain, with genetic drift and population history, the current geographic distribution of most BRCA1 allele frequencies characterized by a large number of recent and rare alleles.
New World crops are therefore potentially useful resources for investigating the still-unresolved question of whether similar changes have been selected independently, resulting in parallel or convergent evolution of the domestication syndrome, or whether different mutations have been selected in different regions, so that similar phenotypes are actually controlled by different genotypes.
