Sentence examples for mutation had previously from inspiring English sources

The first mouse, with the p.Gln176* mutation, had previously been characterized without noting systemic effects [ 18].

We extended our investigations with a cohort of 60 patients with gliomas in which IDH1R132H mutation had previously been determined by DNA sequence analysis.

Seven patients tested for a KRAS mutation had previously received chemotherapy, one was positive for a KRAS mutation and the remaining patients were negative.

detected this mutation in three out of seven analyzed index patients, for whom only one disease-causing DYSF mutation had previously been identified using sequence analysis of all coding exons and flanking intronic boundaries.

The equivalent m.1624C>T MT-TV mutation, as well as the MELAS m.3243A>G MT-TL1 mutation, had previously been introduced into yeast mtDNA and the mitochondrial leucyl or valyl tRNA synthetase were each independently overexpressed.

One of the reasons for carrying out this analysis was that the 5382insC mutation had previously been shown to segregate with the disease in a very large Scottish 'West Lothian' kindred having breast/ovarian carcinoma.

To the best of our knowledge, only one clock gene mutation has previously been investigated in a CH population.

This mutation has previously been shown to render recombinant β3-containing GABAA receptors essentially insensitive to etomidate and propofol.

In particular, we identify a prominent role in the allosteric coupling for the Na+-coordinating residue D421, where mutation has previously been associated with neurological disorders.

The c.618A>C mutation has previously been shown to be absent in 1280 control chromosomes [3].

The AKT1E17K mutation has previously been reported in breast, colorectal and ovarian cancer.