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But each mutation had already been found circulating naturally in influenza viruses.
In the three cases where the causative mutation had already been identified, the most significant association was properly assigned and was ∼100 times more likely than the next highest association using permutation testing.
This missense mutation had already been reported by Kunishima et al., but its appearance in an independent patient cohort supplies reliable evidence for the definite involvement of ACTN1 in CMTP.
Its application to all unaffected women in the kConFab cohort is somewhat artificial because in many cases they were recruited into kConFab after a family mutation had already been found.
This mutation had already been observed before the pandemic (H1N1) 2009 outbreak, for example, it was detected worldwide in healthy patients who had not received antiviral drugs and were infected with seasonal (H1N1) virus during the 2008 09 influenza season (8 ).
Mutations were then randomly distributed across individuals, chromosomes and loci and they switched allele 1 to allele 2. If a mutation occurred at a position where a previous mutation had already occurred, this allele was allowed to return to its previous state (i.e., 1) instead of choosing another position for the mutation but this rate of reverse mutation was very low.
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Admittedly, it is hard to diagnose in each tumor whether the secondary mutation has already existed before drug treatment or not.
Another Caribbean-specific mutation has already been reported: the presence of a threonine deletion in the V3 loop of Trinidad samples (env T319-) [8].
Even if the mutation is of a known gene for which a similarly acting mutation has already been identified, it can still uncover hitherto unidentified phenotypes associated with mutant alleles.
This mutation has already been reported by various authors like (12- 18, 18, 33).
This mutation has already been extensively investigated and found to be associated in different types of cancers [ 9, 19].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com