Sentence examples for mutation groups were from inspiring English sources

In order to determine patterns of brain atrophy at group level, volumetric MRI data from healthy controls and the C9ORF72, MAPT and GRN mutation groups were compared using voxel-based morphometry with the DARTEL toolbox of SPM8 (http://www.fil.ion.ucl.ac.uk/spm) running under Matlab 7.0 (Mathworks).

This grouping was based on the hypothesis that truncating and non-truncating mutation groups are likely to have a different impact in the functional properties of the mutated protein.

Three triple-mutation specimens harboured EGFR E21, and all EGFR E21 mutations in this triplet mutation group were L861Q.

The sample size of the deleterious mutation group was small for both genes, with only 13 and 11 individuals carrying deleterious mutations for BRCA1 and BRCA2 respectively.

The BRCA1/2 negative mutation group is shown in Table 4. BC = breast cancer; CBC = controlateral breast cancer; OC = ovarian cancer; / = no cases; M = male.

Time to tumour progression in the 'classical' mutations group was significantly longer than in the 'wild-type' group (64 vs 16 weeks; P=0.002, Figure 1).

Unlike in the study by Marcus et al [ 13**], no difference in the frequency of the invasive lobular carcinoma or tubular carcinoma between control individuals and the BRCA2 mutations group was identified.

In contrast, the response in the All mutations group was attenuated such that percentages of PgR-positive cells in samples from this group were significantly lower than those of the population-risk group not only before the start of treatment but also for 2 weeks afterwards (P<0.001 by Mann–Whitney U-test at each time point).

Differences in HPV prevalence, p53 mutation prevalence, and pattern of p53 mutations between groups were examined by Fisher's exact test.

However, neither of these differences nor the distribution of all genotypes were significantly different in all pair-wise comparisons of the three groups, or when the BRCA mutation-positive groups were combined in the analyses for each polymorphism.

Mutation rates between different groups were compared using Fisher's exact test.