Sentence examples for mutation gives no from inspiring English sources
The model assumes that the PIG-A mutation gives no fitness advantage to the HSC (neutral drift).
Mutations can alter the relative reproductive fitness of cells - while the relative fitness of normal cells can be defined to be one, mutant cells will have a relative fitness r; r < 1 means a lower relative fitness, r > 1 represents a higher relative fitness and r = 1 means that the mutation gives no reproductive advantage compared to the remaining wild-type population.
This apparent "redundancy" has complicated studies of mammalian serpins, as most serpin null mutations give no discernable mutant phenotype.
In future, one might take advantage of the high sequence conservation of this gene from mouse to human (94%), in order to try and 'knock-in' a human mutation that gives no clinical phenotype until challenged by PQ, i.e. any of those present in known polymorphic mutants.
Bottleneck analyses using the Wilcoxon Signed-Rank test under all known microsatellite mutation models gave no significant result, except for a marginally significant bottleneck under IAM for the low transmission season (Table 2).
It is difficult to imagine that mutations that give no known phenotype in the heterozygous state, and cause a disease in the homozygous state, can be positively selected; therefore in principle (b) seems more likely in this case.
The paternal mutation (c.393 G>T) gave no detectable transcript.
A mutation gives a person about a 60percentt chance of getting the disease.
The mutational meltdown model predicts that given no opposing force, p-endosymbionts should steadily accrue slightly deleterious mutations until extinction.
